of the Kuwait Institute for Medical Specializationj
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Volume 5; Number 1: 2006

Readers who submit answers to the questions that accompany the CME/CPD articles become eligible for CME/CPD credits in Category 1. To claim credit, the reader has to be registered in the MPC Program, the answers should be received by the CME Center before 31st May 2007, and all questions related to the article should have been attempted. Readers would then receive a certificate from the CME Center indicating the credit data.

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After you have completed reading the CME/CPD articles, take the test given. Check T (True) or F (False) to show the correct answer to each question.
Principles of autoimmunity: Part I - Induction of autoimmunity and Part II - Modes of autoimmune damage
Raj Raghupathy
(1 CME credit point)
1.
Immunological tolerance is developed by a process that educates immune cells to distinguish between self and non-self.
 True False
2.
‘Negative selection’ is a process in thymic education during which T cells with receptors for ‘foreign’ antigens are selected for proliferation.
True False
3.
Clonal anergy is a state of induced non-responsiveness to self antigens.
True False
4.
Molecular mimicry is a method for the bypass of tolerance in which hidden molecules are exposed to the immune system.
 True False
5.
The abnormal expression of HLA molecules in the pancreatic islet cells of insulin-dependent diabetes mellitus can be attributed in part to abnormal cytokine regulation.
 True False
6.
In organ-specific autoimmune diseases target cells can be directly damaged by antibodies or cell-mediated immunity.
True False
7.
Blocking antibodies bind to hormone receptors and stimulate exaggerated activity leading to an overproduction of mediators or increased cell growth.
 True False
8.
The immunopathogenesis of the systemic autoimmune disease rheumatoid arthritis can involve both antibodies and T cells.
 True False
9.
Immunosuppressive drugs such as corticosteroids are not found to be therapeutic in autoimmune diseases.
 True False
10.
The targeting of cytokines and cytokine receptors using antibodies has been found to be an effective therapeutic approach to treat autoimmune diseases.
 True False
Skin diseases seen in diabetes mellitus
Nawaf Al-Mutairi
(1 CME credit point)
11. Cutaneous manifestations of diabetes mellitus are seen only with Type 2 diabetes mellitus. True False
12. Cutaneous manifestations of diabetes develop only subsequent to the development of diabetes mellitus. True False
13. Diabetic dermopathy manifests with painful ulcers. True False
14. Necrobiosis lipoidica is seen only in diabetics. True False
15. Diabetic patients may develop waxy skin and limited joint mobility. True False
16. Diabetic bullae show acantholysis as in pemphigus vulgaris. True False
17. Acanthosis nigricans seen in diabetics is never a marker for insulin resistance. True False
18. The perforating disorder seen in diabetics does not show Koebner’s phenomenon. True False
19. Granuloma annulare and necrobiosis lipoidica are both necrobiotic disorders. True False
20. Cutaneous infections are seen more frequently in Type 1 diabetic patients compared to Type 2 patients. True False
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